She is affiliated with UT Health San Antonio at the Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, where she serves as a board-certified neuropathologist and physician-scientist. She currently leads the Neuropathology Core at the South Texas Alzheimer’s Disease Research Center (ADRC), is Co-Director of the Brain Bank at the Biggs Institute, and serves as Medical Director of a CLIA-certified biomarker laboratory.

Her research focuses on TDP-43 proteinopathy and mixed pathologies, as well as the development of digital pathology and large-scale data harmonization. She leads NIH-funded federated digital pathology initiatives across multiple ADRCs. In addition, she is Director of the Nun Study and is nationally recognized for her contributions to neuropathology standardization and data integration.